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Princip je prost: Neuronal stress or neuronal damage induced by intracellular tau pathology can also impact nearby immune cells, such as microglia. Furthermore, microglia can be affected by extracellular tau secreted by neurons with tau pathology and tau filaments leaking from dying cells. Microglia may also be directly involved in stes induced synapse loss and synaptic spreading of tau pathology[, ].
Understanding how microglia sitex to synaptic dysfunction is therefore of critical importance and will be discussed in more detail below.